The utility of splenic imaging parameters in cardiac magnetic resonance for the diagnosis of immunoglobulin light-chain amyloidosis

Abstract Objectives Cardiac Magnetic Resonance (CMR) Imaging is a key test in the diagnosis of cardiac amyloidosis (CA). Extracardiac involvement common light chain (AL) and MRI findings may assist its diagnosis. We sought to investigate utility splenic CMR parameters for CA. Methods Thirty-four patients with AL 32 severe left ventricular hypertrophy setting aortic stenosis (LVH-AS) who completed 3T at time their or LVH-AS were assessed T1, T2 (modified Look-Locker inversion recovery), Extracellular volume (ECV) mapping, late gadolinium enhancement (LGE) imaging heart spleen. Results Age, mass index, wall thickness, ejection fraction, dimensions did not differ significantly between groups. All had involvement. T1 spleen mapping groups but higher median ECV than (AL 46.9%, LVH-AS: 31%, p<0.001), lower short tau recovery (STIR) ratio (AL: 1.7, 2.7, p<0.001) both very good diagnostic performance diagnose AL. identified 16 without. Spleen “normalized” ratio, defined as LGE muscle values exhibited strong correlation excellent discriminate those Conclusion Our show that can identify differentiate them from without amyloidosis. Funding Acknowledgement Type funding sources: None.